Jobs openings
Ausschreibung einer Diplomarbeit am Institut OMCL der Ages PharmMed: Screening for novel viral markers in plasma pools
Exposè:
Virus transmission to a large number of recipients by plasma derivatives is still a severe danger for public health. In the past, several cases of transmission of infectious diseases (including HIV-1, HBV and HCV) by pooled plasma or plasma derivatives have occurred. Introduction of official batch release, PCR screening (nucleic acid amplification techniques) and virus inactivation steps in the manufacturing process has minimized the danger of transmission of these diseases. However, novel viruses especially those resistant to inactivation procedures still pose a risk to recipients of pooled plasma and plasma derivatives. Additionally, globalisation of production of biologicals enhances the danger of illegal trade of insufficiently tested plasma derivatives. Therefore, the goal of this master thesis is to screen pooled plasma of different origin for viral markers including West Nile Virus (WNV) and Hepatitis E (HEV). WNV started to spread in Europe and pigs and wild boar were recently identified as a potential reservoir for autochthonous infections of HEV. For Parvo B19 and Torque Teno (TT), virus quantification and the distribution of the different genotypes according to the origin of plasma pools will be determined. For TT virus little is known about the global distribution of the virus genotypes. Since there are only speculations about diseases associated with TT viruses, epidemiological information might help to find correlations with diseases.
Further experiments are planned to determine the efficiency of virus inactivation and filtrations. Additional analytical methods dependent on preliminary results include Western Blotting, ELISA and virus neutralization assays.
Geplante Dauer der Diplomarbeit: 8 Monate
Geplanter Start: Juli 2011
Bezahlung: 350.-/Monat
Ort: Possingergasse 38, 1160 Wien
Ihre schriftliche Bewerbung richten Sie bitte per E-Mail an:
Frau Margareta Modli, Possingergasse 38, 1160 Wien: margarete.modli@ages.at.
